HORMONA ADRENOCORTICOTROPINA PDF

Hormon adrenokortikotropik adalah hormon yang dihasilkan oleh lobus anterior dalam hormon kelenjar hipofisis atau biasa disebut dengan kelenjar pituitari yang terdiri dari beberapa lobus. Hormon-hormon yang dihasilkan oleh kelenjar pituitari merupakan tropic hormon. Tropic hormon berfungsi mempengaruhi proses sekresi sistem hormon pada manusia dari kelenjar endokrin lainnya. Pada median eminens hipotalamus melalui serabut aferen dan menyebabkan pengeluaran CRH, sekresi ACTH juga dipengaruhi oleh berbagai rangsang sistem saraf pada manusia. Sebagai contoh, rangsangan pada reseptor rasa nyeri diteruskan ke saraf aferen perifer dan traktus spinotalamikus, akhirnya sampai pada median eminens hipotalamus dan menyebabkan sekresi CRH yang kemudian dialirkan ke adenohipofisis yang kemudian melepas ACTH. Mungkin dapat menjelaskan mengapa orang yang sering dilanda emosi cenderung menderita iritasi lambung, karena pada pemberian hormon kortikosteroid sering ditemukan efek samping iritasi lambung.

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More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex.

ACTH is secreted from the anterior pituitary in response to corticotropin-releasing hormone from the hypothalamus.

Corticotropin-releasing hormone itself is inhibited by glucocorticoids, making it part of a classical negative feedback loop. Additional information on the role of ACTH in regulation of adrenal steroid secretion is presented in the sections on the adrenal gland and glucocorticoids. Within the pituitary gland, ACTH is produced in a process that also generates several other hormones.

A large precursor protein named proopiomelanocortin POMC, "Big Mama" is synthesized and proteolytically chopped into several fragments as depicted below. Not all of the cleavages occur in all species and some occur only in the intermediate lobe of the pituitary.

The major attributes of the hormones other than ACTH that are produced in this process are summarized as follows: Lipotropin: Originally described as having weak lipolytic effects, its major importance is as the precursor to beta-endorphin. Beta-endorphin and Met-enkephalin: Opioid peptides with pain-alleviation and euphoric effects. Melanocyte-stimulating hormone MSH : Known to control melanin pigmentation in the skin of most vertebrates.

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ACTH (hormona adrenocorticotropa): quƩ es y enfermedades relacionadas

More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex. ACTH is secreted from the anterior pituitary in response to corticotropin-releasing hormone from the hypothalamus. Corticotropin-releasing hormone itself is inhibited by glucocorticoids, making it part of a classical negative feedback loop. Additional information on the role of ACTH in regulation of adrenal steroid secretion is presented in the sections on the adrenal gland and glucocorticoids. Within the pituitary gland, ACTH is produced in a process that also generates several other hormones. A large precursor protein named proopiomelanocortin POMC, "Big Mama" is synthesized and proteolytically chopped into several fragments as depicted below.

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Hormona adrenocorticotropa: definiciĆ³n, funciones y enfermedades asociadas

Glucocorticoids secreted from the adrenal cortex work to inhibit CRH secretion by the hypothalamus, which in turn decreases anterior pituitary secretion of ACTH. Glucocorticoids may also inhibit the rates of POMC gene transcription and peptide synthesis. The latter is an example of a slow feedback loop, which works on the order of hours to days, whereas the former works on the order of minutes. The half-life of ACTH in human blood is about ten minutes.

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